Orforglipron, an oral GLP-1 receptor agonist developed by Eli Lilly, has shown strong results—Phase III trials demonstrated an average 12.4% body weight loss over 72 weeks, along with improved heart health markers like cholesterol and blood pressure
Convenient and non-invasive, this daily pill could revolutionise treatment access, particularly for those averse to injections or living in areas with less medical infrastructure. It’s easier to store and distribute globally compared to injectables ([turn0search3], [turn0search10]). Orforglipron is expected to be submitted for regulatory approval by late 2025, with a potential UK availability in early to mid-2026
“As a convenient once-daily pill, orforglipron may provide a new option and, if approved, could be readily manufactured and launched at scale for use by people around the world.” — David Ricks, CEO of Eli Lilly
Orforglipron offers a promising new chapter in weight and diabetes management—especially for those seeking effective and flexible treatment. The Vesey can assist with current options through: