Male urological health demands timely expertise to address prostate, sexual and urinary conditions that affect daily life and long-term wellbeing. This guide clarifies the most common urological conditions, explains how specialist urologists diagnose and treat them across the UK, and outlines preventive strategies to maintain prostate health, bladder control and sexual function. You will discover definitions, underlying mechanisms and practical examples for prostate cancer, BPH, erectile dysfunction, urinary incontinence and testicular disorders; learn about PSA screening, imaging and biopsy; explore advanced surgical and non-invasive therapies; and gain actionable lifestyle recommendations to support men’s urological wellbeing into later decades.
Urological conditions in men encompass prostate, sexual and urinary health problems that arise with age or due to infection, inflammation or anatomical changes. Prostate cancer, BPH and erectile dysfunction rank highest by incidence, often presenting with urinary difficulties, sexual dysfunction and pain. Understanding these core conditions clarifies why early detection and specialist referral are essential for effective management and quality of life.
Prostate cancer is a malignant growth in the prostate gland that can obstruct urine flow and spread beyond the capsule. Cancerous cells disrupt normal hormone regulation and urethral patency, causing symptoms such as blood in urine and pelvic discomfort. Early-stage detection via PSA testing and biopsy enables curative surgery or radiotherapy.
Advances in Transperineal Prostate Biopsy for Prostate Cancer Diagnosis
Prostate cancer (PCa) is the most common cancer in men and has the second highest mortality in the USA [1]. In 2018, approximately 164,690 PCa cases were identified, accounting for almost one in five new cancer diagnoses [1]. Although PCa is common worldwide, the detection method and diagnostic technology have remained controversial. Generally, the following two significant problems regarding PCa diagnosis require urgent resolution: (a) prostate-specific antigen (PSA) has been widely adopted for screening PCa; however, the conventional threshold for biopsy (4.0 ng/ml) has been associated with a positive predictive value of approximately 20–30% [2,3]. Thus, a great number of patients undergo unnecessary prostate biopsies. Are there better biomarkers to help phy
Recent advances and current role of transperineal prostate biopsy, Y Bhanji, 2021
Benign prostatic hyperplasia arises from hormonal shifts—especially dihydrotestosterone accumulation—that trigger prostate tissue proliferation. As the gland enlargies it compresses the urethra, producing frequent urination, nocturia and weak stream. Men over 50 typically experience progressive symptoms impacting sleep and daily routines.
Erectile dysfunction occurs when vascular, neurological or hormonal factors prevent erection initiation or maintenance. Arterial insufficiency, diabetes-related neuropathy and low testosterone each compromise penile blood flow or nerve signalling, reducing confidence and intimate satisfaction.
Prostatitis is inflammation of the prostate gland—acute bacterial or chronic non-bacterial—causing pelvic pain and dysuria. Kidney stones form crystalline deposits that obstruct ureters, triggering severe flank pain and haematuria. Urinary incontinence results from sphincter weakness or bladder instability, leading to involuntary leakage that affects social engagement.
Specialist urologists combine patient history, physical examination and targeted tests to map male urological health. A structured diagnostic pathway integrates symptom scoring, blood markers and imaging to pinpoint conditions and guide personalised treatment plans. Close collaboration with radiologists and pathology teams ensures accurate staging and risk assessment.
A urologist is a physician specialised in the urinary and male reproductive systems, overseeing prostate screening, sexual function assessment and management of bladder disorders. They interpret PSA results, perform digital rectal examinations and counsel men on treatment options, balancing efficacy and quality-of-life considerations.
Key diagnostic tests include:
Together these investigations differentiate cancer from BPH, detect prostatitis and quantify urinary obstruction.
Transperineal versus Transrectal Prostate Biopsy: Diagnostic Accuracy and Complications
1. Given the limitations of conventional prostate biopsy, optimised variations of prostate biopsy strategies have emerged to improve the diagnostic rate of prostate cancer. We conducted a systematic review to compare the diagnostic rate and complications of transperineal versus transrectal prostate biopsy.
2. We searched for online publications up to 27 June 2018 in the PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure databases. Relative risk and 95% confidence intervals were used to appraise the diagnostic and complication rates. The pooled relative risk from 11 included studies indicated that transperineal prostate biopsy has the same diagnostic accuracy as transrectal prostate biopsy; however, a significantly lower risk of fever and rectal bleeding was reported for transperineal prostate biopsy. No evidence of publication bias was identified.
3. In conclusion, this review indicated that transperineal and transrectal prostate biopsy have the same diagnostic accuracy, but the transperineal approach has a lower risk of fever and rectal bleeding. Further studies are warranted to confirm these findings and to discover a more effective diagnostic method for prostate cancer.
Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis, H Yan, 2019
Men should consult a urologist if they experience persistent urinary frequency, blood in urine, painful ejaculation or erectile difficulties. Those over 50 may request PSA screening annually, while younger men with sudden severe flank pain or recurrent infections warrant immediate specialist review to exclude stones or prostatitis.
Contemporary prostate therapies range from active surveillance for low-risk cancer to minimally invasive procedures for BPH and chronic prostatitis management. Advancements in laser ablation, robotic surgery and focal therapies enhance precision and reduce recovery time, aligning with individual risk profiles and lifestyle goals.
Prostate cancer treatment includes:
Emerging immunotherapies and gene-targeted drugs show promise in refractory cases.
Transperineal Prostate Biopsy Techniques for Accurate and Safe Diagnosis
As the second most diagnosed cancer worldwide, prostate cancer is confirmed via tissue biopsy. Given the large number of prostate biopsies performed each year, the technique should be as accurate and safe as possible for the patient’s well-being. Transrectal ultrasound-guided prostate biopsy (TRUS-biopsy) is most commonly offered worldwide. Transperineal biopsy (TPP-biopsy), on the other hand, has been gaining popularity due to its superior sensitivity and lower rate of sepsis. This article offers a review of the brachytherapy grid technique used to perform a TPP-biopsy, as well as a discussion of possible variations in the procedure. TPP-biopsy is typically performed under general anaesthesia with the patient in the lithotomy position. Through the perineum, cores of tissue are taken systematically, with or without targeting, under ultrasound guidance. Different fusion techniques (cognitive, MRI-US fusion software, MRI in-bore) can be used to target pre-identified lesions on MRI. The sampling can be performed either
Transperineal prostate biopsy: a review of technique, J Grummet, 2020
Modern BPH options:
ProcedureMechanismBenefitGreenLight LaserVaporises excess tissueRapid symptom relief and short hospital stayTURPResects prostate via transurethral scopeDurable improvement in flow and voidingUroLiftImplants to retract enlarged lobesMinimally invasive with preserved ejaculation
These interventions reduce nocturia and improve peak flow in men with moderate to severe symptoms.
Prostatitis treatment combines antibiotics for bacterial forms with alpha-blockers to relax smooth muscle. Lifestyle modifications—warm baths, prostate massage—and anti-inflammatory regimens alleviate chronic pelvic pain, while pelvic floor physiotherapy supports muscle function and symptom control.
Erectile dysfunction therapies prioritise efficacy, convenience and minimal side effects. Oral PDE5 inhibitors, second-line injections and mechanical devices complement lifestyle optimisation and psychological support to address both physical and emotional contributors to sexual dysfunction.
Oral PDE5 inhibitors block phosphodiesterase type-5 in penile tissue, amplifying nitric oxide–mediated vasodilation to improve blood flow. Sildenafil acts within 30–60 minutes for up to 4 hours, while tadalafil’s extended half-life supports spontaneity with effects lasting up to 36 hours.
Second-line options include intracavernosal alprostadil injections that directly induce erection, vacuum erection devices that draw blood into the penis via negative pressure, and penile implants reserved for severe or refractory cases. These modalities restore function when oral agents are unsuitable or ineffective.
Lifestyle adaptations—regular exercise, weight management, smoking cessation and moderated alcohol—enhance vascular health and hormonal balance. Psychological interventions such as cognitive behavioural therapy and sex therapy address performance anxiety and emotional factors, boosting confidence and treatment adherence.
Male bladder disorders range from overactive bladder to urinary tract infections and kidney stones. Urologists employ symptom questionnaires, flow studies and imaging to distinguish causes, then combine pharmacotherapy, procedural interventions and pelvic floor rehabilitation for tailored relief.
Incontinence often results from sphincter weakness, prostate surgery sequelae or neurological conditions affecting bladder control. Overactive bladder stems from detrusor overactivity triggered by ageing, infection or metabolic factors, causing urgency, frequency and urge incontinence.
Urolithiasis is managed by hydration, analgesia and lithotripsy for stones >5 mm. UTIs require culture-guided antibiotics, increased fluid intake and bladder irrigation when recurrent. Diet modifications to reduce oxalate and salt intake lower stone recurrence.
Pelvic floor muscle training strengthens the external urinary sphincter through targeted contractions. Men benefit from biofeedback-guided regimes and bladder retraining schedules to increase voiding intervals, thereby reducing urgency and leakage episodes.
Testicular disorders include tumours, inflammation and fluid collections that demand prompt evaluation. Awareness of normal testicular anatomy and self-examination techniques underpins early detection, while specialist imaging and surgical expertise guide definitive management.
Testicular cancer often presents as a painless lump or scrotal heaviness. Scrotal ultrasound confirms mass characteristics, followed by radical inguinal orchiectomy to remove the testis and pathological staging. Adjuvant chemotherapy or radiotherapy may follow for seminoma or non-seminoma subtypes.
Epididymitis is inflammation of the epididymis, typically infectious, treated with antibiotics and NSAIDs. Hydrocele is fluid accumulation around the testicle, managed conservatively if small or via surgical hydrocelectomy when symptomatic or enlarging.
Preventative urology emphasises lifestyle, mental wellbeing and timely screening to reduce incidence and progression of urological disorders. A holistic approach integrating diet, exercise and mental health support fosters durable prostate and urinary function beyond age 50.
A diet rich in cruciferous vegetables, lycopene and omega-3 fatty acids modulates inflammation and hormone balance. Regular aerobic exercise preserves cardiovascular health and reduces BPH risk. Smoking cessation and moderate alcohol intake support vascular integrity essential for erectile and urinary function.
Anxiety and depression trigger sympathetic overactivity, worsening urinary urgency and sexual performance. Stress-reduction techniques—mindfulness, counselling and peer support—improve sleep, hormone regulation and adherence to treatment plans, enhancing overall urological outcomes.
Men over 50 should discuss PSA testing with their GP or urologist, particularly those with family history or higher risk profiles. Yearly PSA monitoring and digital rectal examination enable early intervention for asymptomatic prostate cancer and guide decisions on biopsy or surveillance.
Men often wonder about early signs, test reliability and optimal timing for specialist referral to safeguard urological health. Clear answers to these concerns help demystify consultations and encourage prompt professional advice.
Prostate issues typically manifest as urinary hesitancy, weak stream, nocturia and hematuria. Softening of ejaculatory force and pelvic discomfort can also indicate underlying BPH or malignancy.
Erectile dysfunction arises from vascular disease, diabetes, neurological disorders and psychological factors. Treatments range from oral PDE5 inhibitors and injections to vacuum devices, lifestyle changes and therapy, offering high success rates with tailored regimens.
PSA testing measures prostate-specific antigen in blood, with elevated levels indicating increased cancer risk. While sensitive, PSA can rise with BPH or prostatitis; hence, it is most reliable when combined with digital rectal examination and imaging.
A urologist consultation is advised for persistent urinary changes, erectile dysfunction unresponsive to first-line measures, visible blood in urine, or abnormal PSA results. Early specialist involvement ensures accurate diagnosis and personalised care.
Early recognition and specialist management of male urological conditions transform long-term outcomes and quality of life. Advances in diagnostic imaging, minimally invasive procedures and targeted therapies now provide safer, more effective options for prostate, sexual and urinary health. By adopting preventative lifestyle measures and engaging in regular screening, men can maintain robust urological wellbeing and address emerging symptoms with confidence. Continuous collaboration with qualified urologists ensures each treatment plan aligns with individual needs and current clinical best practices. Regular review of mental health, diet and exercise completes a comprehensive approach that safeguards urinary and reproductive function throughout the lifespan.