Lymph node biopsy
What is it? A lymph node biopsy is a medical procedure conducted to collect tissue samples from lymph nodes for diagnostic purposes. Lymph nodes are small, bean-shaped structures that play a vital role in the immune system by filtering lymph fluid and containing immune cells. Biopsy helps healthcare professionals investigate the cause of lymph node enlargement, identify infections, or detect abn
What it is
Most enlarged lymph nodes are reactive (infection) and resolve over 4-6 weeks. Persistent (>6 weeks), painless, firm or progressively enlarging nodes warrant biopsy. Ultrasound-guided core biopsy is first-line; excisional biopsy under GA is reserved for diagnostic-quality requirements (especially for lymphoma).
When this is relevant
- Persistent lymph node enlargement >6 weeks.
- Painless, firm or rubbery node not associated with infection.
- Coexisting "B symptoms" - drenching night sweats, weight loss, fever.
- Multiple enlarged nodes in different regions.
- Known cancer and a new enlarged node suggesting metastatic disease.
How we investigate
Detailed history, examination of all node territories, FBC, LDH, ESR, CRP, viral screen (EBV, CMV, HIV, hepatitis B/C), CT or PET imaging where indicated, ultrasound-guided fine needle aspiration or core biopsy.
Options at The Vesey
- Reactive node monitoring with structured 4-6 week re-examination.
- Ultrasound-guided core biopsy - 20-minute outpatient procedure under local anaesthetic.
- Excisional biopsy - day-case under GA via partner surgical centre for diagnostic-quality samples (lymphoma workup).
- Onward haematology / oncology referral for any malignant histology.
- Infection treatment with cause-directed antibiotics / antiviral therapy where indicated.
How long does an ultrasound-guided core biopsy take? +
The procedure takes approximately 20 minutes under local anaesthetic as an outpatient. You can typically go home within an hour of arrival. Histology results are usually available within 5–7 working days.
Will biopsy spread cancer? +
No. This is a common concern but is not supported by evidence for the core biopsy technique used. The needle passes through normal tissue into the node; the microscopic track has no clinical significance.
When is an excisional biopsy needed instead of a core biopsy? +
When architectural assessment of the whole node is needed — particularly for suspected lymphoma — a larger tissue sample improves diagnostic accuracy. Your consultant will advise which technique is appropriate based on the clinical picture and any imaging.
What happens after the biopsy result? +
If the result is benign-reactive, a structured follow-up plan is arranged. If lymphoma or metastatic malignancy is found, we refer urgently to the appropriate haematology or oncology team and arrange staging imaging. We aim to communicate results within one working day of receiving the pathology report.
Pricing at a glance
Initial consultation £260. Ultrasound-guided core biopsy from £750 all-inclusive. Excisional biopsy day-case quoted individually. Insurance accepted: BUPA, Vitality, AXA, WPA, Cigna, Aviva, Healix.
Book an appointment
When to book
Book if you have a persistent enlarged node, B symptoms, or known cancer with a new enlarged node.
Cost and pathway
Initial consultation £260. Ultrasound-guided core biopsy from £750 all-inclusive. Excisional biopsy day-case quoted individually.
- Open 7 days including Sundays — 8am to 8pm, no weekend surcharge
- No GP referral required — book directly with our general surgical team
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Sutton Coldfield · Birmingham · Walsall · Tamworth · Lichfield · West Midlands · Open 7 days 8am–8pm
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